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Chemical structure of JTK-853

GC32384

JTK-853

Also known as (2R)-4-(5-cyclopropyl-[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]-1-[4-(trifluoromethyl)phenyl]sulfonylpiperazine-2-carboxamide

JTK-853 is a novel, non-nucleoside Hepatitis C Virus (HCV) polymerase inhibitor which shows effective antiviral activity in HCV replicon cells with EC50s of 0·38 and 0·035 ?M in genotype 1a H77 and 1b Con1 strains, respectively

ChemicalCAS954389-09-4MW704.64FormulaC28H23F7N6O4S2
CAS number
954389-09-4
Molecular weight
704.64
Formula
C28H23F7N6O4S2
Solubility
Soluble in DMSO
InChIKey
JQLOVYLALGSISI-HXUWFJFHSA-N
Catalogue number
GC32384
Brand
GLPBIO
Computed properties PubChem CID 57519700 · XLogP 5.7 · TPSA 154 Ų · H-bond donors 1
XLogP
5.7
TPSA
154 Ų
H-bond donors
1
H-bond acceptors
17
Rotatable bonds
8
Heavy atoms
47

SMILES C1CC1C2=NC=C3C(=N2)N=C(S3)N4CCN([C@H](C4)C(=O)NCC5=CC(=C(C=C5)OC(F)(F)F)F)S(=O)(=O)C6=CC=C(C=C6)C(F)(F)F

Computed descriptors from PubChem (CID 57519700), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.