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Chemical structure of JTP 1048196

GB40249

JTP 1048196

Also known as 3-[2-(2-methoxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one

JTP 1048196 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value of 16·1 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex· The lactone structure of JTP 1048196 was transformed to the reactive α,β-unsaturated carbonyl moiety JTP 0819958 which reacts with the cysteine residue of LUBAC, leading to its covalent inhibition in vitro and cellular levels

ChemicalCAS55377-56-5MW282.29FormulaC17H14O4
CAS number
55377-56-5
Molecular weight
282.29
Formula
C17H14O4
InChIKey
DFBPFCSPQHHVSO-UHFFFAOYSA-N
Catalogue number
GB40249
Brand
GLPBIO
Computed properties PubChem CID 4889633 · XLogP 2.7 · TPSA 52.6 Ų · H-bond donors 0
XLogP
2.7
TPSA
52.6 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
21

SMILES COC1=CC=CC=C1C(=O)CC2C3=CC=CC=C3C(=O)O2

Computed descriptors from PubChem (CID 4889633), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.