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Chemical structure of PRN1008

GC31339

PRN1008

Also known as (E)-2-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

PRN1008 (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton's Tyrosine Kinase (BTK), with an IC50 of 1·3 nM

ChemicalCAS1575596-29-0MW665.76FormulaC36H40FN9O3
CAS number
1575596-29-0
Molecular weight
665.76
Formula
C36H40FN9O3
Solubility
DMSO ： ≥ 130 mg/mL (195·27 mM)
InChIKey
LCFFREMLXLZNHE-GBOLQPHISA-N
Catalogue number
GC31339
Brand
GLPBIO
Computed properties PubChem CID 73388818 · XLogP 3.4 · TPSA 139 Ų · H-bond donors 1
XLogP
3.4
TPSA
139 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
8
Heavy atoms
49

SMILES CC(C)(/C=C(\C#N)/C(=O)N1CCC[C@H](C1)N2C3=NC=NC(=C3C(=N2)C4=C(C=C(C=C4)OC5=CC=CC=C5)F)N)N6CCN(CC6)C7COC7

Computed descriptors from PubChem (CID 73388818), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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