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Chemical structure of PRN694

GC30502

PRN694

Also known as 5-(difluoromethyl)-N-[5-[[[(2S)-3,3-dimethylbutan-2-yl]amino]methyl]-1-[[(2R)-1-prop-2-enoylpyrrolidin-2-yl]methyl]benzimidazol-2-yl]thiophene-2-carboxamide

PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0·3 nM and 1·4 nM, respectively

ChemicalCAS1575818-46-0MW543.67FormulaC28H35F2N5O2S
CAS number
1575818-46-0
Molecular weight
543.67
Formula
C28H35F2N5O2S
Solubility
DMSO ： 125 mg/mL (229·92 mM)
InChIKey
NXTKFBGDLDPFLB-PKOBYXMFSA-N
Catalogue number
GC30502
Brand
GLPBIO
Computed properties PubChem CID 90044055 · XLogP 5.4 · TPSA 108 Ų · H-bond donors 2
XLogP
5.4
TPSA
108 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
10
Heavy atoms
38

SMILES C[C@@H](C(C)(C)C)NCC1=CC2=C(C=C1)N(C(=N2)NC(=O)C3=CC=C(S3)C(F)F)C[C@H]4CCCN4C(=O)C=C

Computed descriptors from PubChem (CID 90044055), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.