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Chemical structure of OTS514 hydrochloride

GC25691

OTS514 hydrochloride

Also known as 9-[4-[(2R)-1-aminopropan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one;hydrochloride

OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2·6 nM· OTS514 induces cell cycle arrest and apoptosis

ChemicalCAS2319647-76-0MW400.92FormulaC21H20N2O2S·HCl
CAS number
2319647-76-0
Molecular weight
400.92
Formula
C21H20N2O2S·HCl
Solubility
DMSO: 80 mg/mL (199·54 mM);Water: 80 mg/mL (199·54 mM);Ethanol: 5 mg/mL (12·47 mM)
InChIKey
CQPRMBOOBXSZSP-YDALLXLXSA-N
Catalogue number
GC25691
Brand
GLPBIO
Computed properties PubChem CID 92044487 · TPSA 104 Ų · H-bond donors 4 · H-bond acceptors 4
TPSA
104 Ų
H-bond donors
4
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
27

SMILES CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)[C@@H](C)CN)O.Cl

Computed descriptors from PubChem (CID 92044487), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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