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Chemical structure of VU6005649

GC19381

VU6005649

Also known as 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine

VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0·65 uM and 2·6 uM for mGlu7 receptor and mGlu8 receptor, respectively

ChemicalCAS2137047-43-7MW357.28FormulaC16H12F5N3O
CAS number
2137047-43-7
Molecular weight
357.28
Formula
C16H12F5N3O
Solubility
DMSO ： 50 mg/mL (139·95 mM; Need ultrasonic)
InChIKey
NYBZCKAQIIPSDS-UHFFFAOYSA-N
Catalogue number
GC19381
Brand
GLPBIO
Computed properties PubChem CID 131954513 · XLogP 3.8 · TPSA 39.4 Ų · H-bond donors 0
XLogP
3.8
TPSA
39.4 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
2
Heavy atoms
25

SMILES CC1=NC2=C(C(=NN2C(=C1)C(F)(F)F)C)C3=C(C(=C(C=C3)OC)F)F

Computed descriptors from PubChem (CID 131954513), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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