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Chemical structure of Protein degrader 1 hydrochloride

GC19302

Protein degrader 1 hydrochloride

Also known as (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;hydrochloride

(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein· Protein degrader 1 hydrochloride can be connected to the ligand for protein (e·g·, BCR-ABL1) by a linker to form PROTACs (e·g·, GMB-475)· GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1·11 μM in Ba/F3 cells

ChemicalCAS1448189-80-7MW467.02FormulaC22H31ClN4O3S
CAS number
1448189-80-7
Molecular weight
467.02
Formula
C22H31ClN4O3S
Solubility
DMSO ： 150 mg/mL (321·19 mM);Water ： 50 mg/mL (107·06 mM)
InChIKey
JYRTWGCWUBURGU-MSSRUXLCSA-N
Catalogue number
GC19302
Brand
GLPBIO
Computed properties PubChem CID 118864076 · TPSA 137 Ų · H-bond donors 4 · H-bond acceptors 6
TPSA
137 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
31

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)N)O.Cl

Computed descriptors from PubChem (CID 118864076), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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