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Chemical structure of Protein degrader 1 TFA

GC32433

Protein degrader 1 TFA

Also known as (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid

(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein· Protein degrader 1 TFA can be connected to the ligand for protein (e·g·, BCR-ABL1) by a linker to form PROTACs (e·g·, GMB-475)· GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1·11 μM in Ba/F3 cells

ChemicalCAS1631137-51-3MW544.59FormulaC24H31F3N4O5S
CAS number
1631137-51-3
Molecular weight
544.59
Formula
C24H31F3N4O5S
Solubility
Soluble in DMSO
InChIKey
SGNZARGJXDPTDJ-MSSRUXLCSA-N
Catalogue number
GC32433
Brand
GLPBIO
Computed properties PubChem CID 133053568 · TPSA 174 Ų · H-bond donors 4 · H-bond acceptors 11
TPSA
174 Ų
H-bond donors
4
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
37

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)N)O.C(=O)(C(F)(F)F)O

Computed descriptors from PubChem (CID 133053568), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.