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Chemical structure of TAS-120

GC19156

TAS-120

Also known as 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one

TAS-120 (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor, with IC50s of 3·9, 1·3, 1·6, and 8·3 nM for FGFR 1-4, respectively· TAS-120 inhibits mutant and wild-type FGFR2 with similar IC50s (wild-type FGFR2=0·9nM; V5651=1-3nM; N550H=3·6nM; E566G=2·4nM)

ChemicalCAS1448169-71-8MW418.45FormulaC22H22N6O3
CAS number
1448169-71-8
Molecular weight
418.45
Formula
C22H22N6O3
Solubility
DMSO ： ≥ 29 mg/mL (69·30 mM)
InChIKey
KEIPNCCJPRMIAX-HNNXBMFYSA-N
Catalogue number
GC19156
Brand
GLPBIO
Computed properties PubChem CID 71621331 · XLogP 2 · TPSA 108 Ų · H-bond donors 1
XLogP
2
TPSA
108 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
31

SMILES COC1=CC(=CC(=C1)C#CC2=NN(C3=NC=NC(=C23)N)[C@H]4CCN(C4)C(=O)C=C)OC

Computed descriptors from PubChem (CID 71621331), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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