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Chemical structure of AZ32

GC19047

AZ32

Also known as N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6·2 nM for ATM enzyme, and an IC50 of 0·31 uM for ATM in cell

ChemicalCAS2288709-96-4MW328.37FormulaC20H16N4O
CAS number
2288709-96-4
Molecular weight
328.37
Formula
C20H16N4O
Solubility
DMSO : ≥ 150 mg/mL (456·80 mM)
InChIKey
LCRTUEXVVKVKBD-UHFFFAOYSA-N
Catalogue number
GC19047
Brand
GLPBIO
Computed properties PubChem CID 134814488 · XLogP 3.3 · TPSA 59.3 Ų · H-bond donors 1
XLogP
3.3
TPSA
59.3 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
25

SMILES CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CC=CC=C4

Computed descriptors from PubChem (CID 134814488), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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