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Chemical structure of API-1

GC18374

API-1

Also known as 4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide

API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0·8 uM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane

ChemicalCAS36707-00-3MW337.3FormulaC13H15N5O6
CAS number
36707-00-3
Molecular weight
337.3
Formula
C13H15N5O6
Solubility
DMSO ： 5·8 mg/mL (15·45 mM)
InChIKey
SPBWHPXCWJLQRU-UHFFFAOYSA-N
Catalogue number
GC18374
Brand
GLPBIO
Computed properties PubChem CID 301081 · XLogP -1.9 · TPSA 185 Ų · H-bond donors 5
XLogP
-1.9
TPSA
185 Ų
H-bond donors
5
H-bond acceptors
10
Rotatable bonds
3
Heavy atoms
24

SMILES C1=C(C(=O)C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)C(=O)N

Computed descriptors from PubChem (CID 301081), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.