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Chemical structure of APIO-EE-07

GB40099

APIO-EE-07

Also known as (3E)-5-fluoro-3-[(E)-4-(4-nitrophenyl)-2-oxobut-3-enylidene]-1H-indol-2-one

APIO-EE-07 is a dual-target inhibitor of RSK1 and MSK2· APIO-EE-07 inhibited cell growth and induced apoptosis and also increased expression of BA1 as well as cleaved caspase-3 and -PARP in colon cancer cells by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1

ChemicalCAS1606160-46-6MW338.29FormulaC18H11FN2O4
CAS number
1606160-46-6
Molecular weight
338.29
Formula
C18H11FN2O4
InChIKey
MHGVFCIOFWQTHT-VVNOOFQYSA-N
Catalogue number
GB40099
Brand
GLPBIO
Computed properties PubChem CID 74221214 · XLogP 2.8 · TPSA 92 Ų · H-bond donors 1
XLogP
2.8
TPSA
92 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
25

SMILES C1=CC(=CC=C1/C=C/C(=O)/C=C/2\C3=C(C=CC(=C3)F)NC2=O)[N+](=O)[O-]

Computed descriptors from PubChem (CID 74221214), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.