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Chemical structure of NPS-2143

GC16943

NPS-2143

Also known as 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile

NPS-2143 is a calcification drug that acts as an antagonist of the calcium-sensing receptor (CaSR) and consequently stimulates the release of parathyroid hormone

ChemicalCAS284035-33-2MW408.93FormulaC24H25ClN2O2
CAS number
284035-33-2
Molecular weight
408.93
Formula
C24H25ClN2O2
Solubility
≥ 40·9mg/mL in DMSO
InChIKey
PZUJQWHTIRWCID-HXUWFJFHSA-N
Catalogue number
GC16943
Brand
GLPBIO
Computed properties PubChem CID 6918446 · XLogP 5 · TPSA 65.3 Ų · H-bond donors 2
XLogP
5
TPSA
65.3 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
8
Heavy atoms
29

SMILES CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O

Computed descriptors from PubChem (CID 6918446), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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