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Chemical structure of LY2835219

GC16822

LY2835219

Also known as N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid

LY2835219 (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively

ChemicalCAS1231930-82-7MW602.7FormulaC27H32F2N8·CH4O3S
CAS number
1231930-82-7
Molecular weight
602.7
Formula
C27H32F2N8·CH4O3S
Solubility
≥ 30·15mg/mL in DMSO
InChIKey
NCJPFQPEVDHJAZ-UHFFFAOYSA-N
Catalogue number
GC16822
Brand
GLPBIO
Computed properties PubChem CID 71576678 · TPSA 138 Ų · H-bond donors 2 · H-bond acceptors 12
TPSA
138 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
7
Heavy atoms
42

SMILES CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O

Computed descriptors from PubChem (CID 71576678), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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