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Chemical structure of Tyrosine kinase-IN-1

GC34026

Tyrosine kinase-IN-1

Also known as (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)-(5-methyl-1H-imidazol-2-yl)methylidene]-1H-indol-2-one

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively

ChemicalCAS705946-27-6MW445.53FormulaC26H28FN5O
CAS number
705946-27-6
Molecular weight
445.53
Formula
C26H28FN5O
Solubility
DMSO ： ≥ 62·5 mg/mL (140·28 mM)
InChIKey
DMQYDVBIPXAAJA-VHXPQNKSSA-N
Catalogue number
GC34026
Brand
GLPBIO
Computed properties PubChem CID 10433653 · XLogP 4.4 · TPSA 73.1 Ų · H-bond donors 3
XLogP
4.4
TPSA
73.1 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
33

SMILES CCN1CCC(CC1)NC2=CC\3=C(C=C2)NC(=O)/C3=C(/C4=CC(=CC=C4)F)\C5=NC=C(N5)C

Computed descriptors from PubChem (CID 10433653), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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