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Chemical structure of JZL184

GC14390

JZL184

Also known as (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate

JZL184 is a potent, selective and irreversible inhibitor of monoacylglycerol lipase (MAGL), which blocks the hydrolysis of 2-arachidonoylglycerol (2-AG) in the brain membrane with an IC50 value of 8nM

ChemicalCAS1101854-58-3MW520.49FormulaC27H24N2O9
CAS number
1101854-58-3
Molecular weight
520.49
Formula
C27H24N2O9
Solubility
≥ 20·35mg/mL in DMSO
InChIKey
SEGYOKHGGFKMCX-UHFFFAOYSA-N
Catalogue number
GC14390
Brand
GLPBIO
Computed properties PubChem CID 25021165 · XLogP 4.2 · TPSA 133 Ų · H-bond donors 1
XLogP
4.2
TPSA
133 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
38

SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]

Computed descriptors from PubChem (CID 25021165), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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