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Chemical structure of Dovitinib

GC13547

Dovitinib

Also listed as Dovitinib (TKI-258, CHIR-258)

Dovitinib (TKI-258, CHIR-258) (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively· Dovitinib (TKI-258, CHIR-258) has potent antitumor activity

ChemicalCAS405169-16-6MW392.43FormulaC21H21FN6O
CAS number
405169-16-6
Molecular weight
392.43
Formula
C21H21FN6O
Solubility
≥ 36·35mg/mL in DMSO
InChIKey
PIQCTGMSNWUMAF-UHFFFAOYSA-N
Catalogue number
GC13547
Brand
GLPBIO
Computed properties PubChem CID 135398510 · XLogP 1.6 · TPSA 90.3 Ų · H-bond donors 3
XLogP
1.6
TPSA
90.3 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
2
Heavy atoms
29

SMILES CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N

Computed descriptors from PubChem (CID 135398510), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.