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Chemical structure of Dovitinib (TKI258) Lactate

GC10165

Dovitinib (TKI258) Lactate

Also known as 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one;2-hydroxypropanoic acid;hydrate

Dovitinib (TKI258) Lactate (TKI258 lactate hydrate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively

ChemicalCAS915769-50-5MW500.52FormulaC24H29FN6O5
CAS number
915769-50-5
Molecular weight
500.52
Formula
C24H29FN6O5
Solubility
≥ 168·2mg/mL in Water
InChIKey
QDPVYZNVVQQULH-UHFFFAOYSA-N
Catalogue number
GC10165
Brand
GLPBIO
Computed properties PubChem CID 135611162 · TPSA 149 Ų · H-bond donors 6 · H-bond acceptors 10
TPSA
149 Ų
H-bond donors
6
H-bond acceptors
10
Rotatable bonds
3
Heavy atoms
36

SMILES CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N.O

Computed descriptors from PubChem (CID 135611162), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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