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Chemical structure of KPT-276

GC12142

KPT-276

Also known as (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one

inhibitor of nuclear export (SINE) and CRM1, orally bioavailable

ChemicalCAS1421919-75-6MW426.26FormulaC16H10F8N4O
CAS number
1421919-75-6
Molecular weight
426.26
Formula
C16H10F8N4O
Solubility
≥ 19·85mg/mL in DMSO
InChIKey
JCHAWRDHMUSLMM-UPHRSURJSA-N
Catalogue number
GC12142
Brand
GLPBIO
Computed properties PubChem CID 71496742 · XLogP 3.6 · TPSA 51 Ų · H-bond donors 0
XLogP
3.6
TPSA
51 Ų
H-bond donors
0
H-bond acceptors
11
Rotatable bonds
3
Heavy atoms
29

SMILES C1C(CN1C(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)(F)F

Computed descriptors from PubChem (CID 71496742), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.