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Chemical structure of MI-773 (SAR405838)

GC11547

MI-773 (SAR405838)

Also known as (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

MI-773 (SAR405838) (MI-77301), an analog of MI-773, is a highly potent and selective MDM2-p53 interaction inhibitor· MI-773 (SAR405838) binds to MDM2 with a Ki of 0·88 nM· MI-773 (SAR405838) induces apoptosis and has potent antitumor activity

ChemicalCAS1303607-60-4MW562.5FormulaC29H34Cl2FN3O3
CAS number
1303607-60-4
Molecular weight
562.5
Formula
C29H34Cl2FN3O3
Solubility
≥ 17·2mg/mL in DMSO
InChIKey
IDKAKZRYYDCJDU-AEPXTFJPSA-N
Catalogue number
GC11547
Brand
GLPBIO
Computed properties PubChem CID 53476877 · XLogP 5.3 · TPSA 90.5 Ų · H-bond donors 4
XLogP
5.3
TPSA
90.5 Ų
H-bond donors
4
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
38

SMILES CC(C)(C)C[C@H]1[C@@]2([C@H]([C@@H](N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

Computed descriptors from PubChem (CID 53476877), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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