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Chemical structure of LEE011

GC10842

LEE011

Also known as 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide

LEE011 (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex

ChemicalCAS1211441-98-3MW434.54FormulaC23H30N8O
CAS number
1211441-98-3
Molecular weight
434.54
Formula
C23H30N8O
Solubility
≥ 10·88mg/mL in DMSO
InChIKey
RHXHGRAEPCAFML-UHFFFAOYSA-N
Catalogue number
GC10842
Brand
GLPBIO
Computed properties PubChem CID 44631912 · XLogP 2.2 · TPSA 91.2 Ų · H-bond donors 2
XLogP
2.2
TPSA
91.2 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
32

SMILES CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5

Computed descriptors from PubChem (CID 44631912), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.