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Chemical structure of TH301

GB40388

TH301

Also known as 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide

TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2· It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells· TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics

ChemicalCAS450338-32-6MW485.98FormulaC24H24ClN3O4S
CAS number
450338-32-6
Molecular weight
485.98
Formula
C24H24ClN3O4S
InChIKey
DDCUCVXSGYHWRJ-UHFFFAOYSA-N
Catalogue number
GB40388
Brand
GLPBIO
Computed properties PubChem CID 4653191 · XLogP 3.8 · TPSA 98.7 Ų · H-bond donors 1
XLogP
3.8
TPSA
98.7 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
33

SMILES COC1=CC=C(C=C1)N2C(=C3CS(=O)(=O)CC3=N2)NC(=O)C4(CCCC4)C5=CC=C(C=C5)Cl

Computed descriptors from PubChem (CID 4653191), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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