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Chemical structure of PDK1 inhibitor 2610

GB40316

PDK1 inhibitor 2610

Also known as 2-[4-[8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]acetonitrile;hydrochloride

Potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively· Also inhibits PI3K p110α, p110β, p110δ, and p110γ (IC50 values 64 nM, 432 nM , 98 nM, and 67 nM, respectively)

ChemicalCAS2108463-93-8MW421.88FormulaC25H15N5·HCl
CAS number
2108463-93-8
Molecular weight
421.88
Formula
C25H15N5·HCl
InChIKey
RUXNLVOZJZTQAS-UHFFFAOYSA-N
Catalogue number
GB40316
Brand
GLPBIO
Computed properties PubChem CID 122129988 · TPSA 67.4 Ų · H-bond donors 1 · H-bond acceptors 4
TPSA
67.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
31

SMILES C1=CC(=CN=C1)C#CC2=CC3=C4C(=CN=C3C=C2)N=CN4C5=CC=C(C=C5)CC#N.Cl

Computed descriptors from PubChem (CID 122129988), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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