GB40312
PAWI-2
Also known as 1-[4-[(4-methyl-2,3-dihydroquinoxalin-1-yl)sulfonyl]phenyl]pyrrolidin-2-one
PAWI-2 is an inhibitor which targets both Wnt signaling (IC50 value of 11 nM) and ATM/p53 (EC50 value of 1·9 nM for p53)· PAWI-2 binds tubulin and potently activates mitotic stress signaling to stabilize p53 and inhibit Wnt/β-catenin transactivation of downstream genes in colorectal cancer cells· Moreover, PAWI-2 inhibits cellular proliferation of androgen-sensitive and androgen-insensitive cells (LNCaP and PC-3, respectively)
ChemicalCAS1448427-02-8MW371.45FormulaC19H21N3O3S
- CAS number
- 1448427-02-8
- Molecular weight
- 371.45
- Formula
- C19H21N3O3S
- InChIKey
- HKMFKYDGIJGBER-UHFFFAOYSA-N
- Catalogue number
- GB40312
- Brand
- GLPBIO
Computed properties PubChem CID 89699521 · XLogP 1.9 · TPSA 69.3 Ų · H-bond donors 0
- XLogP
- 1.9
- TPSA
- 69.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Rotatable bonds
- 3
- Heavy atoms
- 26
SMILES CN1CCN(C2=CC=CC=C21)S(=O)(=O)C3=CC=C(C=C3)N4CCCC4=O
Computed descriptors from PubChem (CID 89699521), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il