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Chemical structure of NMDAR-TRPM4 blocker C19 dihydrochloride - FMP-A-02 | Aliudanexin

GB40296

NMDAR-TRPM4 blocker C19 dihydrochloride - FMP-A-02 | Aliudanexin

Also known as 2-[3-(aminomethyl)pyrrolidin-1-yl]-N-(2,4,5-trichlorophenyl)acetamide;dihydrochloride

C19 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 1·1 μM for NMDA-induced cell death in hippocampal neurons· This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration· Potent neuroprotectant·NMDAR-TRPM4 blocker C8 is available as NMDAR-TRPM4 blocker C8 dihydrochloride

ChemicalCAS2241128-93-6MW409.57FormulaC13H16Cl3N3O·2HCl
CAS number
2241128-93-6
Molecular weight
409.57
Formula
C13H16Cl3N3O·2HCl
InChIKey
KKZAEWKBOQYGHO-UHFFFAOYSA-N
Catalogue number
GB40296
Brand
GLPBIO
Computed properties PubChem CID 138039902 · TPSA 58.4 Ų · H-bond donors 4 · H-bond acceptors 3
TPSA
58.4 Ų
H-bond donors
4
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
22

SMILES C1CN(CC1CN)CC(=O)NC2=CC(=C(C=C2Cl)Cl)Cl.Cl.Cl

Computed descriptors from PubChem (CID 138039902), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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