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Chemical structure of CXL146

GB40165

CXL146

Also known as prop-2-ynyl 2-amino-6-(2-methyl-4-pyridinyl)-4-(2-oxo-2-prop-2-ynoxyethyl)-4H-chromene-3-carboxylate

CXL146 is a selective inhibitor of HL60/MX2 cell proliferation by targeting GRP78 overexpression· CXL146 treatment activated the unfolded protein response (UPR)· CXL146-induced UPR activation led to a series of downstream events, including extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase activation, which contributed to CXL146-induced apoptosis

ChemicalCAS2244586-41-0MW416.43FormulaC24H20N2O5
CAS number
2244586-41-0
Molecular weight
416.43
Formula
C24H20N2O5
InChIKey
HLNKVUKTJMCVKX-UHFFFAOYSA-N
Catalogue number
GB40165
Brand
GLPBIO
Computed properties PubChem CID 145954090 · XLogP 2.8 · TPSA 101 Ų · H-bond donors 1
XLogP
2.8
TPSA
101 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
31

SMILES CC1=NC=CC(=C1)C2=CC3=C(C=C2)OC(=C(C3CC(=O)OCC#C)C(=O)OCC#C)N

Computed descriptors from PubChem (CID 145954090), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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