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Chemical structure of CaSR antagonist 18c

GB40140

CaSR antagonist 18c

Also known as 6-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]-N-(2-phenoxyethyl)-2-(3,4,5-trimethoxyphenyl)pyridine-3-carboxamide

Calcium-sensing receptor (CaSR) antagonist (IC50: 76 nM); potential anabolic agent for the treatment of osteoporosis

ChemicalCAS802916-30-9MW557.64FormulaC32H35N3O6
CAS number
802916-30-9
Molecular weight
557.64
Formula
C32H35N3O6
InChIKey
FCBOUJYKAGWYQM-DEOSSOPVSA-N
Catalogue number
GB40140
Brand
GLPBIO
Computed properties PubChem CID 11410354 · XLogP 5 · TPSA 111 Ų · H-bond donors 3
XLogP
5
TPSA
111 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
14
Heavy atoms
41

SMILES COC1=CC(=CC(=C1OC)OC)C2=C(C=CC(=N2)N[C@@H](CC3=CC=CC=C3)CO)C(=O)NCCOC4=CC=CC=C4

Computed descriptors from PubChem (CID 11410354), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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