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Chemical structure of Z-Leu-Arg-AMC

GA23847

Z-Leu-Arg-AMC

Also known as benzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate

Z-LR-AMC, a fluorogenic substrate for cathepsin L, S, and V, human tissue kallikrein, and the falcipains I - III· Z-LR-AMC is the preferred substrate of falcipain II, a hemoglobin-degrading cysteine protease from Plasmodium falciparum, one of the most promising targets for antimalarial drug design· Z-LR-AMC is used for assaying cathepsin K, an enzyme involved in osteoclastic bone resorption

ChemicalCAS156192-32-4MW578.67FormulaC30H38N6O6
CAS number
156192-32-4
Molecular weight
578.67
Formula
C30H38N6O6
Solubility
DMSO ： 100 mg/mL (172·81 mM; Need ultrasonic)
InChIKey
XDHCDHWCFOQOCP-ZEQRLZLVSA-N
Catalogue number
GA23847
Brand
GLPBIO
Computed properties PubChem CID 25108601 · XLogP 2.5 · TPSA 187 Ų · H-bond donors 5
XLogP
2.5
TPSA
187 Ų
H-bond donors
5
H-bond acceptors
7
Rotatable bonds
14
Heavy atoms
42

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)OCC3=CC=CC=C3

Computed descriptors from PubChem (CID 25108601), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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