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Chemical structure of Z-Leu-Leu-4,5-dehydro-Leu-aldehyde

GA23851

Z-Leu-Leu-4,5-dehydro-Leu-aldehyde

Also known as benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopent-4-en-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

The peptide aldehyde SIB1281 inhibited the formation of β- and γ-secretase derived amyloid β-protein (Aβ) with IC?? = 1·8 µM and stimulated the formation of α-secretase derived soluble amyloid precursor protein (sα) with an EC?? of 250 nM

ChemicalCAS181139-85-5MW473.61FormulaC26H39N3O5
CAS number
181139-85-5
Molecular weight
473.61
Formula
C26H39N3O5
Solubility
Soluble in DMSO
InChIKey
ZXWQFMXXHLZICN-VABKMULXSA-N
Catalogue number
GA23851
Brand
GLPBIO
Computed properties PubChem CID 25181407 · XLogP 4.9 · TPSA 114 Ų · H-bond donors 3
XLogP
4.9
TPSA
114 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
15
Heavy atoms
34

SMILES CC(C)C[C@@H](C(=O)N[C@@H](CC(=C)C)C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

Computed descriptors from PubChem (CID 25181407), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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