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Chemical structure of TRH-βNA

GA23641

TRH-βNA

Also known as (2S)-N-[(2S)-3-(4H-imidazol-4-yl)-1-[[(2S)-1-naphthalen-2-ylpyrrolidine-2-carbonyl]amino]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

A sensitive and highly specific substrate for a rapid assay of rat brain TRH-deamidating enzyme (prolyl endopeptidase)· TRH-βNA is also hydrolyzed by another TRH-degrading enzyme, pyroglutamyl peptidase II (thyroliberinase), which seems to play a key role in terminating the biological activity of neuronally released TRH

ChemicalCAS73644-58-3MW488.55FormulaC26H28N6O4
CAS number
73644-58-3
Molecular weight
488.55
Formula
C26H28N6O4
Solubility
Soluble in DMSO
InChIKey
VHPCPKIDRHHIHE-WDHNVLQZSA-N
Catalogue number
GA23641
Brand
GLPBIO
Computed properties PubChem CID 194532 · XLogP 1.4 · TPSA 132 Ų · H-bond donors 3
XLogP
1.4
TPSA
132 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
36

SMILES C1C[C@H](N(C1)C2=CC3=CC=CC=C3C=C2)C(=O)NC(=O)[C@H](CC4C=NC=N4)NC(=O)[C@@H]5CCC(=O)N5

Computed descriptors from PubChem (CID 194532), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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