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Chemical structure of TRH-Gly

GA23640

TRH-Gly

Also known as 2-[[(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid

TRH-Gly is the direct precursor of TRH; the glycine is cleaved by an α-amidating enzyme to form the C-terminal amide· Significant concentrations of the tetrapeptide, however, have been found in hypothalamus, pituitary, thyroid, and peripheral blood of rats as well as in human cerebrospinal fluid· Several data suggest that the peptide is also biologically active

ChemicalCAS85344-77-0MW420.43FormulaC18H24N6O6
CAS number
85344-77-0
Molecular weight
420.43
Formula
C18H24N6O6
Solubility
Soluble in DMSO
InChIKey
CSVCLHYFVGHUCM-AVGNSLFASA-N
Catalogue number
GA23640
Brand
GLPBIO
Computed properties PubChem CID 121906 · XLogP -2.5 · TPSA 174 Ų · H-bond donors 5
XLogP
-2.5
TPSA
174 Ų
H-bond donors
5
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
30

SMILES C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)NCC(=O)O

Computed descriptors from PubChem (CID 121906), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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