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Chemical structure of TRH-AMC

GA23639

TRH-AMC

Also known as (2S)-N-[(2S)-3-(1H-imidazol-5-yl)-1-[(2S)-2-[(4-methyl-2-oxochromen-7-yl)carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Fluorogenic substrate used in in a coupled assay for TRH-degrading ectoenzyme· TRH-DE removes N-terminal pyroglutamic acid which yields His-Pro-AMC, a substrate for the coupled enzyme DPPIV

ChemicalCAS190836-86-3MW520.55FormulaC26H28N6O6
CAS number
190836-86-3
Molecular weight
520.55
Formula
C26H28N6O6
Solubility
Soluble in DMSO
InChIKey
MZUKTPVHFSNFMB-UFYCRDLUSA-N
Catalogue number
GA23639
Brand
GLPBIO
Computed properties PubChem CID 95565998 · XLogP -0.6 · TPSA 163 Ų · H-bond donors 4
XLogP
-0.6
TPSA
163 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
38

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CN=CN4)NC(=O)[C@@H]5CCC(=O)N5

Computed descriptors from PubChem (CID 95565998), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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