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Chemical structure of H-Tyr-Tyr-OH

GA22991

H-Tyr-Tyr-OH

Also known as (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid

Narai-Kanayama and Aso showed that Tyr-Tyr and Tyr-Tyr-Tyr (H-5230) efficiently inhibit angiotensin I-converting enzyme (ACE) from rabbit lung, their IC?? values were 34 μM and 51 μM, respectively· These two tyrosine peptides exhibited a mix of competitive and noncompetitive inhibitions

ChemicalCAS1050-28-8MW344.37FormulaC18H20N2O5
CAS number
1050-28-8
Molecular weight
344.37
Formula
C18H20N2O5
Solubility
DMSO : 100 mg/mL (290·39 mM; Need ultrasonic); H2O : 100 mg/mL (290·39 mM; Need ultrasonic)
InChIKey
JAQGKXUEKGKTKX-HOTGVXAUSA-N
Catalogue number
GA22991
Brand
GLPBIO
Computed properties PubChem CID 70590 · XLogP -1.9 · TPSA 133 Ų · H-bond donors 5
XLogP
-1.9
TPSA
133 Ų
H-bond donors
5
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
25

SMILES C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O)N)O

Computed descriptors from PubChem (CID 70590), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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