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Chemical structure of H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH

GA22977

H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH

Also known as (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid

The octapeptide YIYGSFK selected from a random combinatorial peptide library is a much more specific and efficient substrate for the Src-family protein tyrosine kinase than cdc2 (6-20), a peptide derived from 34p cdc2· Its Km value for p60 c-src (55 µM) is about 6·4-fold lower than that of the cdc2 (6-20) substrate

ChemicalCAS165190-42-1MW877.01FormulaC44H60N8O11
CAS number
165190-42-1
Molecular weight
877.01
Formula
C44H60N8O11
Solubility
Soluble in DMSO
InChIKey
VWMNLTJCSXEGRK-RJMZHZDQSA-N
Catalogue number
GA22977
Brand
GLPBIO
Computed properties PubChem CID 11297487 · XLogP -0.8 · TPSA 325 Ų · H-bond donors 12
XLogP
-0.8
TPSA
325 Ų
H-bond donors
12
H-bond acceptors
13
Rotatable bonds
26
Heavy atoms
63

SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)N

Computed descriptors from PubChem (CID 11297487), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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