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Chemical structure of Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH

GA21390

Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH

Also known as (2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-(2,4-dinitroanilino)pentanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]pentanoyl]amino]-3-hydroxypropanoic acid

The FRET peptide Dnp-RPLALWRS is the best fluorogenic substrate developed for matrilysin (also called punctuated metalloproteinase 1, PUMP-1 or MMP-7) thus far· In addition to good kinetic parameters (kcat/Km = 1·9 · 10? M?¹s?¹), it showed good solubility in assay buffer

ChemicalCAS172666-82-9MW1164.29FormulaC52H77N17O14
CAS number
172666-82-9
Molecular weight
1164.29
Formula
C52H77N17O14
Solubility
Soluble in DMSO
InChIKey
QGUMMYMULJJAFN-VMTJQXTBSA-N
Catalogue number
GA21390
Brand
GLPBIO
Computed properties PubChem CID 131849665 · XLogP 1.6 · TPSA 501 Ų · H-bond donors 14
XLogP
1.6
TPSA
501 Ų
H-bond donors
14
H-bond acceptors
17
Rotatable bonds
31
Heavy atoms
83

SMILES C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]

Computed descriptors from PubChem (CID 131849665), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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