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Chemical structure of Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized)

GA20533

Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized)

Also known as (2S)-2-acetamido-N-[(2S)-1-[[(4R,7S,10S,13S,19S,22S,25R)-4-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-amino-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]-10,22-bis(4-aminobutyl)-7-(3-amino-3-oxopropyl)-13,19-bis(3-carbamimidamidopropyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacos-25-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]butanediamide

This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²?I-labeled APP to heparin (IC??= 10??M)· The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth

ChemicalCAS289634-54-4MW1918.24FormulaC81H128N32O19S2
CAS number
289634-54-4
Molecular weight
1918.24
Formula
C81H128N32O19S2
Solubility
Soluble in DMSO
InChIKey
QRODTQMBYJNICI-GMBGMYOLSA-N
Catalogue number
GA20533
Brand
GLPBIO
Computed properties PubChem CID 90471281 · XLogP -9.4 · TPSA 903 Ų · H-bond donors 30
XLogP
-9.4
TPSA
903 Ų
H-bond donors
30
H-bond acceptors
28
Rotatable bonds
49
Heavy atoms
134

SMILES C[C@H]([C@@H](C(=O)N[C@@H](CC1=CNC=N1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CNC=N3)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CCC(=O)N)CCCCN)CCCNC(=N)N)CCCNC(=N)N)CCCCN)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC(=O)N)NC(=O)C)O

Computed descriptors from PubChem (CID 90471281), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.