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Chemical structure of Acetyl-(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) amide

GA20526

Acetyl-(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) amide

Also known as (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-acetamido-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-amino-4-oxobutanoic acid

The pentapeptide Ac-LPFFD-NH? (iAβ5p) is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation· iAβ5p acts as a β-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain· A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimer`s disease (AD) models is additionally reported for iAβ5p

ChemicalCAS339990-02-2MW678.79FormulaC35H46N6O8
CAS number
339990-02-2
Molecular weight
678.79
Formula
C35H46N6O8
Solubility
Soluble in DMSO
InChIKey
DFIDZYQHBGZLHZ-ZIUUJSQJSA-N
Catalogue number
GA20526
Brand
GLPBIO
Computed properties PubChem CID 9896197 · XLogP 1.8 · TPSA 217 Ų · H-bond donors 6
XLogP
1.8
TPSA
217 Ų
H-bond donors
6
H-bond acceptors
8
Rotatable bonds
17
Heavy atoms
49

SMILES CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC(=O)O)C(=O)N)NC(=O)C

Computed descriptors from PubChem (CID 9896197), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.