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Chemical structure of Ac-Arg-Ser-Leu-Lys-AMC

GA20487

Ac-Arg-Ser-Leu-Lys-AMC

Also known as (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-6-amino-N-(4-methyl-2-oxochromen-7-yl)hexanamide

Ac-RSLK-AMC, a fluorogenic substrate for Site-1 protease (S1P), a mammalian subtilisin-related serine protease that cleaves sterol regulatory element-binding proteins (SREBPs)· The peptide sequence RSLK corresponds to the internal propeptide cleavage site that generates active S1P

ChemicalCAS259176-76-6MW701.82FormulaC33H51N9O8
CAS number
259176-76-6
Molecular weight
701.82
Formula
C33H51N9O8
Solubility
Soluble in DMSO
InChIKey
ZVPQHIMGLOTCBK-CQJMVLFOSA-N
Catalogue number
GA20487
Brand
GLPBIO
Computed properties PubChem CID 99647851 · XLogP -1.2 · TPSA 282 Ų · H-bond donors 9
XLogP
-1.2
TPSA
282 Ų
H-bond donors
9
H-bond acceptors
10
Rotatable bonds
20
Heavy atoms
50

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C

Computed descriptors from PubChem (CID 99647851), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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