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Chemical structure of (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)

GA20040

(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)

Also known as (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid

This peptide substrate corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site· It has been used for assaying β-secretase activity

ChemicalCAS186142-28-9MW1179.25FormulaC50H78N14O19
CAS number
186142-28-9
Molecular weight
1179.25
Formula
C50H78N14O19
Solubility
Soluble in DMSO
InChIKey
JONOLKHIDOKDGP-RDICLXJSSA-N
Catalogue number
GA20040
Brand
GLPBIO
Computed properties PubChem CID 9876897 · XLogP -7.1 · TPSA 565 Ų · H-bond donors 18
XLogP
-7.1
TPSA
565 Ų
H-bond donors
18
H-bond acceptors
21
Rotatable bonds
39
Heavy atoms
83

SMILES C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)N

Computed descriptors from PubChem (CID 9876897), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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