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Chemical structure of (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675)

GA20039

(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675)

Also known as (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acid

SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L)· The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products

ChemicalCAS150234-52-9MW1023.07FormulaC44H66N10O18
CAS number
150234-52-9
Molecular weight
1023.07
Formula
C44H66N10O18
Solubility
Soluble in DMSO
InChIKey
YRFQRUMVFYWMKL-OLQHGCFBSA-N
Catalogue number
GA20039
Brand
GLPBIO
Computed properties PubChem CID 131637395 · XLogP -5.6 · TPSA 471 Ų · H-bond donors 15
XLogP
-5.6
TPSA
471 Ų
H-bond donors
15
H-bond acceptors
19
Rotatable bonds
33
Heavy atoms
72

SMILES C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)N

Computed descriptors from PubChem (CID 131637395), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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