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Chemical structure of SGC-CLK-1

GC92005

SGC-CLK-1

Also known as 4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)-N-[3-methoxy-5-(trifluoromethyl)phenyl]pyrimidin-2-amine

SGC-CLK-1 is an inhibitor of CDC-like kinase 1 (Clk1) and Clk2 (IC50s = 13 and 4 nM, respectively)

ChemicalCAS748142-15-6MW416.4FormulaC19H15F3N6O2
CAS number
748142-15-6
Molecular weight
416.4
Formula
C19H15F3N6O2
Solubility
DMSO： Sparingly soluble： 1–10 mg/ml
InChIKey
GJYVLTPTDBQQCY-UHFFFAOYSA-N
Catalogue number
GC92005
Brand
GLPBIO
Computed properties PubChem CID 6539389 · XLogP 3.6 · TPSA 86.5 Ų · H-bond donors 1
XLogP
3.6
TPSA
86.5 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
5
Heavy atoms
30

SMILES COC1=NN2C(=C(C=N2)C3=NC(=NC=C3)NC4=CC(=CC(=C4)C(F)(F)F)OC)C=C1

Computed descriptors from PubChem (CID 6539389), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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