Loading...
Chemical structure of PDGFRα kinase inhibitor 2

GC76980

PDGFRα kinase inhibitor 2

Also known as 4-(chloromethyl)-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

PDGFRα kinase inhibitor 2 (compound 1), an Imatinib analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6·95 μM, 2·45 μM, 1·39 μM for ABL1 wt, KIT wt, PDGFRR wt

ChemicalCAS404844-11-7MW429.9FormulaC24H20ClN5O
CAS number
404844-11-7
Molecular weight
429.9
Formula
C24H20ClN5O
Solubility
DMSO： 17·5 mg/mL (40·71 mM; ultrasonic and warming and heat to 60°C)
InChIKey
WUGWDFMSJPJUEZ-UHFFFAOYSA-N
Catalogue number
GC76980
Brand
GLPBIO
Computed properties PubChem CID 10181075 · XLogP 4.3 · TPSA 79.8 Ų · H-bond donors 2
XLogP
4.3
TPSA
79.8 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
31

SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CCl)NC3=NC=CC(=N3)C4=CN=CC=C4

Computed descriptors from PubChem (CID 10181075), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.