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Chemical structure of PDGFRα kinase inhibitor 1

GC65366

PDGFRα kinase inhibitor 1

Also known as N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively

ChemicalCAS2209053-93-8MW586.69FormulaC34H34N8O2
CAS number
2209053-93-8
Molecular weight
586.69
Formula
C34H34N8O2
Solubility
DMSO ： 260 mg/mL (443·16 mM; Need ultrasonic)
InChIKey
NWVOHJOHQOHBMB-UHFFFAOYSA-N
Catalogue number
GC65366
Brand
GLPBIO
Computed properties PubChem CID 129318936 · XLogP 3.8 · TPSA 116 Ų · H-bond donors 2
XLogP
3.8
TPSA
116 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
11
Heavy atoms
44

SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN(CCN(C)C)C(=O)C3=CN=CC=C3)NC4=NC=CC(=N4)C5=CN=CC=C5

Computed descriptors from PubChem (CID 129318936), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.