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Chemical structure of JMV7048

GC75775

JMV7048

Also known as N-[7-[1-benzyl-5-[(2,4,6-trimethylphenyl)sulfonylamino]benzimidazol-2-yl]heptyl]-6-[4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazin-1-yl]hexanamide

JMV7048 is an effective PROTAC degrader targeting PXR (Pregnane X Receptor) with a DC50 of 379 nM

ChemicalCAS2871774-88-6MW957.19FormulaC53H64N8O7S
CAS number
2871774-88-6
Molecular weight
957.19
Formula
C53H64N8O7S
Solubility
DMSO： 100 mg/mL (104·47 mM; Need ultrasonic)
InChIKey
BFWFCERABLRJQY-UHFFFAOYSA-N
Catalogue number
GC75775
Brand
GLPBIO
Computed properties PubChem CID 166132878 · XLogP 7.3 · TPSA 192 Ų · H-bond donors 3
XLogP
7.3
TPSA
192 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
21
Heavy atoms
69

SMILES CC1=CC(=C(C(=C1)C)S(=O)(=O)NC2=CC3=C(C=C2)N(C(=N3)CCCCCCCNC(=O)CCCCCN4CCN(CC4)C5=CC6=C(C=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O)CC8=CC=CC=C8)C

Computed descriptors from PubChem (CID 166132878), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.