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Chemical structure of JND3229

GC65436

JND3229

Also known as N-[4-[3-(2-chlorophenyl)-7-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]cyclohexyl]propanamide

JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5·8, 6·8 and 30·5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively· JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo· JND3229 can be used in cancer research, especially in non-small cell carcinoma

ChemicalCAS2260886-64-2MW617.18FormulaC33H41ClN8O2
CAS number
2260886-64-2
Molecular weight
617.18
Formula
C33H41ClN8O2
Solubility
DMSO ： 12·5 mg/mL (20·25 mM; Need ultrasonic)
InChIKey
WVLWGBZNXIVAKC-UHFFFAOYSA-N
Catalogue number
GC65436
Brand
GLPBIO
Computed properties PubChem CID 137628688 · XLogP 5 · TPSA 96.9 Ų · H-bond donors 2
XLogP
5
TPSA
96.9 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
44

SMILES CCC(=O)NC1CCC(CC1)N2C3=NC(=NC=C3CN(C2=O)C4=CC=CC=C4Cl)NC5=CC(=C(C=C5)N6CCN(CC6)C)C

Computed descriptors from PubChem (CID 137628688), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.