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Chemical structure of G-5758

GC75748

G-5758

Also known as 1-phenyl-N-[2,3,6-trifluoro-4-[[3-[2-[[(3S,5S)-5-fluoropiperidin-3-yl]amino]pyrimidin-4-yl]-2-pyridinyl]oxy]phenyl]methanesulfonamide

G-5758 is an orally available IRE1α inhibitor with an IC50 of 38 nM for XBP1s

ChemicalCAS2413455-99-7MW588.58FormulaC27H24F4N6O3S
CAS number
2413455-99-7
Molecular weight
588.58
Formula
C27H24F4N6O3S
Solubility
DMSO： 100 mg/mL (169·90 mM; Need ultrasonic)
InChIKey
RBOAUACOQMQNBF-ROUUACIJSA-N
Catalogue number
GC75748
Brand
GLPBIO
Computed properties PubChem CID 156701868 · XLogP 3.9 · TPSA 127 Ų · H-bond donors 3
XLogP
3.9
TPSA
127 Ų
H-bond donors
3
H-bond acceptors
13
Rotatable bonds
9
Heavy atoms
41

SMILES C1[C@@H](CNC[C@H]1F)NC2=NC=CC(=N2)C3=C(N=CC=C3)OC4=CC(=C(C(=C4F)F)NS(=O)(=O)CC5=CC=CC=C5)F

Computed descriptors from PubChem (CID 156701868), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.