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Chemical structure of MK-1468

GC75607

MK-1468

Also known as (2S)-N-[7-chloro-6-[4-[(3R,4R)-4-hydroxy-3-methyloxolan-3-yl]piperazin-1-yl]isoquinolin-3-yl]-6-oxaspiro[2.5]octane-2-carboxamide

MK-1468 is a high selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 0·8 nM

ChemicalCAS2769107-89-1MW501.02FormulaC26H33ClN4O4
CAS number
2769107-89-1
Molecular weight
501.02
Formula
C26H33ClN4O4
Solubility
DMSO： 125 mg/mL (249·49 mM; Need ultrasonic)
InChIKey
ISEBFQYGEPKLRU-RZTXVSJASA-N
Catalogue number
GC75607
Brand
GLPBIO
Computed properties PubChem CID 163277830 · XLogP 2 · TPSA 87.2 Ų · H-bond donors 2
XLogP
2
TPSA
87.2 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
35

SMILES C[C@]1(COC[C@@H]1O)N2CCN(CC2)C3=C(C=C4C=NC(=CC4=C3)NC(=O)[C@H]5CC56CCOCC6)Cl

Computed descriptors from PubChem (CID 163277830), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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