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Chemical structure of SZUH280

GC75467

SZUH280

Also known as 1-[[4-[2-[2-[4-[[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]phenyl]methyl]-N-hydroxyindole-6-carboxamide

SZUH280 is a potent and selective PROTAC HDAC8 degrader with a DC50 of 0·58 μM in A549 cells

ChemicalCAS2770263-77-7MW706.7FormulaC36H34N8O8
CAS number
2770263-77-7
Molecular weight
706.7
Formula
C36H34N8O8
Solubility
DMSO： 116·67 mg/mL (165·09 mM; Need ultrasonic)
InChIKey
OCXICBCMNKOWFI-UHFFFAOYSA-N
Catalogue number
GC75467
Brand
GLPBIO
Computed properties PubChem CID 166642477 · XLogP 1.9 · TPSA 199 Ų · H-bond donors 4
XLogP
1.9
TPSA
199 Ų
H-bond donors
4
H-bond acceptors
11
Rotatable bonds
14
Heavy atoms
52

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=CN(N=N4)CCOCCOC5=CC=C(C=C5)CN6C=CC7=C6C=C(C=C7)C(=O)NO

Computed descriptors from PubChem (CID 166642477), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.