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Chemical structure of TH-Z835

GC75312

TH-Z835

Also known as 4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine

TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1·6 μM

ChemicalCAS2766209-50-9MW498.66FormulaC30H38N6O
CAS number
2766209-50-9
Molecular weight
498.66
Formula
C30H38N6O
Solubility
DMSO： 7·14 mg/mL (14·32 mM; ultrasonic and warming and heat to 60°C)
InChIKey
KIWVGCSJQTTZJO-VHYCJAOWSA-N
Catalogue number
GC75312
Brand
GLPBIO
Computed properties PubChem CID 163360077 · XLogP 4.8 · TPSA 56.8 Ų · H-bond donors 1
XLogP
4.8
TPSA
56.8 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
37

SMILES CC1=C2C(=CC=C1)C=CC=C2N3CCC4=C(C3)N=C(N=C4N5CC6CCC(C5)N6)OC[C@@H]7CCCN7C

Computed descriptors from PubChem (CID 163360077), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.