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Chemical structure of PPI-2458

GC75220

PPI-2458

Also known as [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-[(2R)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate

PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2)

ChemicalCAS431077-35-9MW424.53FormulaC22H36N2O6
CAS number
431077-35-9
Molecular weight
424.53
Formula
C22H36N2O6
Solubility
DMSO： ≥ 100 mg/mL (235·55 mM)
InChIKey
QBDVVYNLLXGUGN-XGTBZJOHSA-N
Catalogue number
GC75220
Brand
GLPBIO
Computed properties PubChem CID 6918653 · XLogP 2.4 · TPSA 116 Ų · H-bond donors 2
XLogP
2.4
TPSA
116 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
9
Heavy atoms
30

SMILES CC(C)[C@H](C(=O)N)NC(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]3([C@H](O3)CC=C(C)C)C

Computed descriptors from PubChem (CID 6918653), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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